The creation of intravenous solutions, has led the standard practice of using glass for packaging. Having a glass package for parenteral drugs has been tested and studied in the biopharma industry, giving reasoning to why having glass containers are currently the best solution for parenteral packaging. Although, it may seem like the “best” solution as of right now, visual inspections and other human interventions has shown many other issues that involve contamination and defects.
The industry is always trying to improve and find better ways to lessen the number of defects of any type of drug—especially parenteral drugs. The pharmaceutical industry needs to build better packaging that will ensure a safe and reliable outcome of manufacturing and delivering of these parenteral drugs.
The blow-fill-seal (B/F/S) technology was introduced as a solution to ensure less contamination for parenteral drugs. A blow-fill-seal container is part of an automated manufacturing process that allows for these bottles to be filled and sealed in a matter of seconds. These containers must be filled with a specific B/F/S machine. This quick process reduces the number of particles and other contaminations that could enter if exposed longer.
Blow-fill-seal has been used for commercial use for inhalation market products for over 20 years and has passed many trials for a variety of biologic drugs—such as parenteral drugs. More testing is occurring it ensure quality of the B/F/S manufacturing opposed to glass packaging.
With InQuest Science's Identifier System, all data can be tracked and traced into our system, comparing both glass containers and B/F/S technology. Reports are generated and could be used to show what packaging product is better for specific parenteral drugs. Our system is used to help the manufacturing workflow and reduce defects. Improvement in the manufacturing industry is always the goal.
